| | | | | growth in human knees using autologous |
| Autologus Cartilage Cell Transplant | | | | mesenchymal stem cells.[2] An advantage to this |
| | | | | approach is that a person's own stem cells are used, |
| Overview | | | | avoiding transmission of genetic diseases. It is also |
| | | | | minimally invasive, minimally painful and has a very |
| Knee cartilage replacement therapy | | | | short recovery period.... |
| Articular cartilage, most notably that which is found in | | | | |
| the knee joint, is generally characterized by very low | | | | Osteochondral Autograft (OATS) |
| friction, high wear resistance, and poor regenerative | | | | This technique/repair requires that the surgeon |
| qualities. It is responsible for much of the | | | | transplant sections of bone and cartilage. First, the |
| compressive resistance and load bearing qualities of | | | | damaged section of bone and cartilage is removed |
| the knee joint and, without it, walking is painful to | | | | from the joint. Then a new healthy dowel of bone |
| impossible. Osteoarthritis is a common condition of | | | | with its cartilage covering is removed from the same |
| cartilage failure that can lead to limited range of | | | | joint and transplanted or grafted into the hole left |
| motion, bone damage and invariably, pain. | | | | from removing the old damaged bone and cartilage. |
| Due to a combination of acute stress and chronic | | | | The healthy bone and cartilage are taken from areas |
| fatigue, osteoarthritis directly manifests itself in a | | | | of low stress in the joint so as to prevent weakening |
| wearing away of the articulating surface and, in | | | | the joint. Depending on the severity and overall size |
| extreme cases, bone can be exposed in the joint. | | | | of the damage multiple plugs or dowels may be |
| Some additional examples of cartilage failure | | | | required to adequately repair the joint. A similar |
| mechanisms include cellular matrix linkage rupture, | | | | treatment is known as mosaicplasty, and is talked |
| chondrocyte protein synthesis inhibition, and | | | | about in the next paragraph.... |
| chondrocyte apoptosis. There are several different | | | | |
| repair options available for cartilage damage or | | | | Grafting |
| failure.... | | | | There are three methods of grafting cartilage |
| | | | | defects, including periosteal grafting, osteochondral |
| Non-surgical treatments | | | | grafting (mosaicplasty), and articular cartilage paste |
| Osteoarthritis is the second leading cause of disability | | | | grafting. Periosteal grafts are harvested from the |
| in the elderly population in the United States. It is a | | | | perichondrial tissue and grafted to the articular |
| degenerative disorder that generally starts off | | | | cartilage defect. Given low long-term success rates, |
| relatively mild and escalates with time and wear. For | | | | perichondrial grafting alone has not been clinically |
| those patients experiencing mild to moderate | | | | accepted as a particularly excellent therapy.... |
| symptoms, the disorder can be dealt with by several | | | | |
| non-surgical treatments... | | | | Joint replacement |
| | | | | Total joint replacement is reserved for the most |
| Non-biological treatments | | | | severe and recalcitrant forms of osteoarthritis. When |
| This type of repair, short of total joint replacement, | | | | other forms of treatment fail or when patients are |
| can be divided into three groups. Treatments that | | | | unlikely to succeed with lesser therapies, the last |
| remove the diseased and undermined cartilage with | | | | option to treat defective cartilage is to replace all or |
| an aim to stop inflammation and pain include shaving | | | | part of the joint. In knee joint replacement, the worn |
| (chondrectomy) and debridement. Another group of | | | | out surfaces of the knee are resurfaced with metal |
| treatments consists of a range of abrasive | | | | and plastic, replacing the poorly functioning natural |
| procedures aimed at triggering cartilage production, | | | | joint with new surfaces that slide together smoothly. |
| such as drilling, microfracture surgery, chondroplasty, | | | | The dysfunctional joint is removed and pain is |
| and spongialization. Laser assisted treatments, | | | | relieved. Total knee replacement is considered a |
| currently experimental, compose a third category; | | | | relatively routine surgery with a 95% success rate at |
| they combine the removal of diseased cartilage with | | | | 20 years. There are more than 300,000 total knee |
| cartilage reshaping and also induce cartilage | | | | replacements in the United States each year. The |
| proliferation.... | | | | average patient age is between 65 and 75. Of these |
| | | | | surgeries, approximately 80% are unilateral (only one |
| Autologous chondrocyte implantation (ACI) and | | | | knee replaced) and 20% are bilateral. Interestingly, |
| Carticel | | | | women undergo the procedure more often than |
| Despite advances in materials science and innovations | | | | men, making up 60% of the patient population... |
| in knee repair, no current therapy can mimic the | | | | |
| extraordinary biomechanical properties of cartilage. | | | | |
| This notion drives initiatives in cell-based replacement | | | | |
| technologies, such as autologous chondrocyte | | | | Please log on to : |
| implantation (ACI). In the United States, Genzyme | | | | Send your query : Get a Quote |
| Corporation provides the only FDA approved ACI | | | | |
| treatment, Carticel.... | | | | We Care Core Values |
| | | | | We have a very simple business model that keeps |
| Autologous Mesenchymal Stem Cell Transplant | | | | you as the centre. |
| For years, the concept of harvesting stem cells and | | | | Having the industry’s most elaborate and |
| re-implanting them into one's own body to | | | | exclusive Patient Care and Clinical Coordination teams |
| regenerate organs and tissues has been embraced | | | | stationed at each partner hospital, we provide you |
| and researched in animal models. In particular, | | | | the smoothest and seamless care ever imagined. |
| mesenchymal stem cells have been shown in animal | | | | With a ratio of one Patient Care Manager to five |
| models to regenerate cartilage[1]. Recently, there has | | | | patients our patient care standards are unmatched |
| been a published case report of successful cartilage | | | | across the sub continent. |